4:25 p.m. ET | FOX
Matchup rating: 88.3 | Spread: SEA -3 (53.5)
What to watch for: Wanna see a shootout? This matchup has all the makings of one. The Seahawks' top three running backs are all question marks due to injuries, which could force them to focus their game plan around MVP front-runner Russell Wilson and his receivers. Their defense has already allowed the most yards through six games in NFL history and could again be without safety Jamal Adams. That's a bad combination against an excellent playcaller in Kyle Shanahan. -- Brady Henderson
Bold prediction: Last week might have been National Tight Ends Day, but Sunday will be 49ers tight end George Kittle's day. Kittle will go for 150-plus yards and score at least once against a Seahawks defense that is struggling to stop everybody and has allowed an average of 14.8 yards per catch to tight ends, 31st in the league. -- Nick Wagoner
Stat to know: San Francisco quarterback Jimmy Garoppolo has the third-shortest average pass distance (6.5 air yards) and the fifth-worst interception rate (3.0%) since the start of last season, including playoffs. He's the only QB to rank in the bottom five in both categories.
What to know for fantasy: Seahawks receiver Tyler Lockett is doing some historic things through seven weeks, but he has been held in check over his past seven meetings with the 49ers (8.1 fantasy points per game). See Week 8 rankings.
Betting nugget: Seattle is 13-4 ATS against San Francisco since the start of the 2012 season. Read more.
Wagoner's pick: Seahawks 31, 49ers 27
Henderson's pick: Seahawks 38, 49ers 35
FPI prediction: SEA, 50.3% (by an average of 0.2 points)
Matchup must-reads: 49ers' YAC Bros the latest addition to Bay Area's fraternal scene ... Dunlap is Seahawks' latest attempt to trade for a better defense ... 49ers lose Samuel, Wilson for multiple weeks ... Seahawks' Lockett continues to show knack for the improbable
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November 01, 2020 at 12:06PM
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Points should be easy to come by in Seahawks-49ers matchup - Seattle Seahawks Blog- ESPN - ESPN
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